Life Sciences
Medicinal Chemistry Services
- Hit Identification
- Library synthesis
- Focused synthesis
- Lead Generation
- Lead Optimization
- Pre-selected compounds synthesis and AMES batches
- Analytical of Pre-selection compounds
Computational Chemistry Services
Structure-based Methods
- Small molecule library screening using docking and scoring
- Fragment-based design (De novo compound design)
- Structure-based pharmacophore modeling and library screening
- Focused library design using protein and ligand complex
Ligand-based Methods
- Feature, shape and field-based pharmacophore models
- QSAR models and virtual library screening
- Scaffold hopping and bioisoster replacement
- Virtual library screening using ligand based models
- Focused library generation (De novo scaffold design) & enumeration
Cheminformatics Techniques for Compound Selection
- Similarity & diversity analysis
- Physicochemical property filters
- ~5MM virtual compounds from 18 vendor companies
- Novelty analysis (IP potential)
Process R&D and Custom Synthesis
We can do large scale non-GLP synthesis
- Route design and optimization
- Scale-up of multi-step procedures up to kilogram quantities
- Consistent batches in grams
- Manufacturing of pharmaceutical raw materials and advanced intermediates
- Identify Quality Attributes, Critical Quality Attributes
- Risk assessment, Process Robustness
- Identify potentially Critical Process Parameters, Solvent, temperature, addition etc.
- Experimental data and scientific discussion, clarity in process, in-process controls
- Analytical studies, Impurity profiling and cause of formation, controllable process Tech transfer to kilo lab or pilot plant
- Large scale purifications
Library Design & Synthesis
Target Based
- Kinases / GPCRs / Ion – channel / Nuclear Receptors and other enzymes
- Designed Molecules are filtered on the basis of Lipinski Filters
- Segregated as Drug-like, Lead-like, etc.
Fragment based
- Libraries of small molecules (Molecular weight < 300)
- Building molecules and Pharmacophore generation
Advance Chemical Analoging Approach
Natural product based
- Libraries from existing Natural Products
- Scaffolds inspired from existing Natural Products (Linear Hybrids, Diversity oriented synthesis of Natural Product-inspired Scaffolds)
De Novo libraries
- Libraries on novel scaffolds
Analytical Services
Capabilities
- Routine Assay
- Raw material characterization as per latest Pharmacopoeia (USP, BP, EP, IP, JP)
- Method development as per ICH guidelines
- Method validation as per ICH guidelines
- Impurity isolation and characterization
- Trace metal analysis using AAS and ICP-MS techniques
- Organic Volatile Impurities and Residual Solvents as per USP
- Heavy metals
- Extractables and Leachables analysis
Biology Services
We can do large scale non-GLP synthesis
- Bioinformatics Consulting
- Invivo Pharmacokinetics
- Invitro stability studies
- Invitro ADMET
- In vivo non-glp exploratory toxicology
- Drug Permeation and Transport
- Drug Drug interactions
- Biomarker development
- Cytogenetics
- Microbiology (Strain development)
- Research methodology development